TOPLINE: 

In contrast with a wholesome omnivore food plan, a wholesome vegan food plan led to vital enchancment in low-density lipoprotein ldl cholesterol (LDL-C) in addition to fasting insulin and weight reduction in a randomized managed trial of equivalent twins. 

METHODOLOGY:  

  • Researchers randomly assigned 22 pairs of wholesome grownup equivalent twins (34 girls, imply age 39 years, imply physique mass index 25.9) to a wholesome vegan or omnivore food plan (1 twin per pair) for 8 weeks.
  • For the primary 4 weeks, diet-specific meals had been supplied through a meal supply service. For the ultimate 4 weeks, contributors ready their very own diet-appropriate meals/snacks.
  • The first final result was change in LDL-C; secondary outcomes included modifications in physique weight and fasting insulin. 

TAKEAWAY:

  • After 8 weeks, twins consuming a vegan food plan confirmed a major imply lower of 13.9 mg/dL in LDL-C in contrast with twins consuming an omnivorous food plan.
  • The vegan food plan additionally led to a major imply lower of two.9 μIU/mL in fasting insulin and 1.9 kg in physique weight after 8 weeks in contrast with the omnivore food plan, though weight reduction was noticed in each food plan teams. 
  • The vegan food plan group additionally had a bigger however nonsignificant absolute median lower in fasting HDL-C, triglycerides, vitamin B12, glucose, and trimethylamine N-oxide ranges at 8 weeks.

IN PRACTICE: 

“Our outcomes corroborate a earlier discovering exhibiting that consuming a vegan food plan can enhance cardiovascular well being. Clinicians could take into account recommending plant-based diets to scale back cardiometabolic danger elements, in addition to aligning with environmental advantages,” the researchers concluded. 

SOURCE: 

The research, with first writer Matthew J. Landry, PhD, RDN, Stanford Prevention Analysis Middle, Stanford College Faculty of Drugs, California, was revealed on-line November 30 in JAMA Community Open

LIMITATIONS: 

The grownup twin inhabitants was usually wholesome and findings will not be generalizable to different populations. The pattern dimension was small, and the period of intervention was quick and there was no follow-up interval, which limits insights on stability and sustainability of the diets. 

DISCLOSURES: 

Funding was supplied by the Vogt Basis, and grants from Stanford College and the Nationwide Coronary heart, Lung, and Blood Institute. Landry has no related disclosures. One writer reported receiving funding from Past Meat outdoors of this research. 

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